Stem cells are cells that are necessary for the body to replenish, maintain, and regenerate cells that are lost daily, and have the following two characteristics.
1. Differentiation: Create cells such as blood, nerves, bones, muscles and blood vessels.
2. Self-renewal ability: Produces its own copy cells to replenish and repair defective cells.
If it is earlier, the symptoms will improve immediately after administration, and it is expected that the repair effect will continue for several months. (Effects vary from person to person.)
Although there are individual differences, we will administer stem cells while observing the health status and observing the patient for 3 months, 6 months, and 12 months after the initial treatment.
Stem cells have the property of accumulating at the damaged site called the “homing phenomenon”. Therefore, it is known that when stem cells are injected into blood, they naturally accumulate at the target site and exert a therapeutic effect.
(Homing phenomenon: A phenomenon in which stem cells transplanted from the periphery reach a niche (lesion site). Induction signals such as cytokines and adhesion factors are secreted from the lesion site, and the stem cells sense the induction signals and accumulate in the lesion site. However, it is known to exert a therapeutic effect.)
・Fat is safer and less burdensome to the body than bone marrow harvest.
・Similar to bone marrow-derived mesenchymal stem cells, adipose-derived stem cells have the ability to differentiate into fat, bone, and cartilage, as well as the ability to differentiate into muscle, which is not found in bone marrow-derived cells.
・It has a strong proliferation ability.
・There is little effect of aging due to proliferation and deterioration of bone differentiation capacity.
Stem cells generally support human growth, and there are more stem cells in childhood than in adults. Stem cells are also present when they mature and stop apparent growth and serve to recruit cells when the tissue is damaged throughout life. Tissue stem cells such as brain and heart are difficult to separate from the body and difficult to use for treatment, so mesenchymal stem cells that can be easily collected from fat etc. are receiving attention.
Mesenchymal stem cells: relatively easy to obtain from adult bone marrow, adipose tissue and dental pulp, and differentiate into not only adipocytes, osteoblasts, adipocytes, muscle cells, chondrocytes but also cells such as internal organs and neurons
I have the ability. In recent years, it has been reported that mesenchymal stem cells have an immunosuppressive action and have a property of accumulating in tumors, use of mesenchymal stem cells to prevent rejection after transplantation, and cancer gene therapeutic drug Mesenchymal stem cells have also been used in the field of tissue engineering, with research being conducted as carriers.
Stem cells include pluripotent stem cells that can be created from any cells in the body, such as embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells), and tissue stem cells obtained from tissues such as skin and blood It will be. Tissue stem cells that supplement lost cells include bone marrow stem cells and adipose stem cells. Adipose stem cells are characterized by less ethical issues and cancer risk than ES cells and iPS cells, and less invasion of the patient’s body than bone marrow stem cells.
Since we use adipose stem cells cultured from the fat of the patient himself, there is no rejection reaction due to transplantation. It is a highly safe treatment with a low risk of tumor formation found in iPS cells and ES cells. In addition, the wound when collecting fat is about 5 mm and it is a surgery that does not burden the body, and there is no ethical problem like ES cells
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